back to circadian rhythms? treating bipolar depression with modafinil

August 7, 2007

Modafinil (more commonly known as Provigil), a drug approved for use in sleep apnea, narcolepsy, and shift work disorder, appears to be helpful with bipolar depression.

The article notes that the manufacturer supplied both the modafinil and the matching placebo.   I wonder how much placebo costs?  Are there places that manufacture brand-name placebo?  I mean, there must be, for researchers to run studies.


future potential bipolar treatment: dorky glasses?

July 28, 2007

Stabilizing circadian rhythms can be helpful with bipolar disorder, and there’s even one treatment called (straightforwardly) “dark therapy”, in which complete darkness is used to reset the circadian clock (there’s some limited data supporting this). Jim Phelps of bipolar site psycheducation.org has written about circadian rhythms and dark therapy, and now has a paper out looking to get around the issue where nobody actually wants to be in total darkness for long periods of time except maybe when they’re sleeping.

The paper doesn’t have a controlled trial, just a series of case studies where people with bipolar disorder were able to fall asleep faster when they were undergoing treatment involving amber-tinted safety goggles, which block some wavelengths of light that knock melatonin levels down (e.g., the goggles keep melatonin at night-time levels).

So, don’t go out and buy dorky goggles just yet, and maybe not at all depending on how the evidence turns out, but if you’re interested in the circadian-rhythm angle this might be something to keep an eye on.